What the Research Really Says About Supplements for Endometriosis Healing

Before we dive in — if you’re starting or deepening your endometriosis healing journey, I created a gentle resource to help you feel more grounded each day:
Daily Healing Affirmations (Free Printable)
A soft, supportive ritual you can add to your mornings or evenings to help regulate your mind and nervous system during your healing journey.
When you’re navigating life with endometriosis, it’s natural to reach a point where you start asking deeper questions:
“What else can I do?”
“What supports my body beyond pain meds and surgery?”
“What supplements actually help — and which ones should I leave alone?”
A major review, Dietary supplements for treatment of endometriosis: A review (PMCID: PMC8972862), examined exactly that. Today, I’m breaking down the real science in warm, simple language — the way I wish someone had done for me years ago.
This is not about “miracle cures.”
This is about evidence, nourishment, and building a gentle partnership with your body.
What the Study Looked At
The review analyzed clinical, animal, and cell-based studies on vitamins, minerals, and supplements commonly used by women with endometriosis. This included:
• Omega-3s
• Vitamin D
• Curcumin
• Resveratrol
• Quercetin
• NAC
• Magnesium
• Zinc
• Selenium
• Vitamins C & E
• Propolis
• Probiotics
• EGCG
• Alpha-lipoic acid (ALA)
The focus was on inflammation, oxidative stress, hormone signaling, immune responses, and lesion growth — the core pathways that make endo so complex.
What the Evidence Suggests
Omega-3 Fatty Acids
One of the most promising supplement categories.
Research highlights benefits like:
• Lower inflammation
• Less prostaglandin production (pain-causing compounds)
• Improved immune response
• Potential reduction in lesion size (animal studies)
Practical takeaway:
Incorporate wild salmon, sardines, chia, flax, or a high-quality fish oil supplement.
Vitamin D
Vitamin D influences:
• Inflammation pathways
• Angiogenesis (blood vessel growth in lesions)
• Immune responses
• Hormonal balance
Human trial results are mixed — some show pain relief, others don’t — but deficiency is extremely common and worth addressing.
Practical takeaway:
Get your vitamin D level checked and supplement if needed.
Curcumin, Resveratrol, & Other Polyphenols
These compounds:
• Reduce inflammation
• Slow cell growth
• Improve oxidative balance
• Support immune function
Most strong results come from cell/animal studies — but they align with the benefits of an anti-inflammatory diet.
Practical takeaway:
Try turmeric lattes, berries, herbs, dark leafy greens, and high-quality supplements.
Magnesium, Zinc & Trace Minerals
These support:
• Nerve + muscle relaxation
• Hormonal balance
• Immune system regulation
• Stress responses (critical for endo)
Practical takeaway:
Magnesium glycinate at night is one of the best additions for cramp relief and sleep quality.
Probiotics & Gut Support
Endo and gut health are deeply connected. Probiotics may help with:
• Bloating
• Estrogen metabolism
• Gut inflammation
• Immune support
Practical takeaway:
Eat fermented foods and consider a gentle probiotic.
Gentle Reminder
This study does not claim supplements will “cure” endometriosis.
They are tools — supportive tools — not the whole solution.
The real magic lies in how you nourish your entire system:
your emotions, your nervous system, your boundaries, your gut, and your inflammation patterns.
This is why everything we do inside PinkProverb focuses on healing from the inside out.
How to Integrate Supplements into Your Endo Healing Plan
1. Start with testing
Check your vitamin D, hormone markers, inflammatory markers, magnesium, and zinc.
2. Use food as your foundation
Supplements support the body — but food fuels it.
(Anti-inflammatory eating, ginger, turmeric, berries, greens, salmon.)
3. Add supplements intentionally
Omega-3s, magnesium glycinate, vitamin D, NAC, probiotics — as guided by your provider.
4. Track how you feel
Notice changes in:
• Pain
• Bloating
• Mood
• Sleep
• Cycle length
• Energy
5. Layer with daily rituals
Tea, soft mornings, warm baths, stretching, journaling, sleep hygiene.
If you’re ready for deeper emotional and spiritual healing alongside the physical work, explore:
Healing Through Words Journal Kit
A beautifully structured journal designed to help you release emotional tension, process stress, and reconnect with your body. Perfect for women healing from endometriosis, chronic stress, or emotional overwhelm.
Important Caveats
The review emphasizes one thing repeatedly:
We need more clinical trials.
Evidence is promising — especially for omega-3s, curcumin, NAC, and vitamin D — but supplements should be used with your healthcare team, not instead of them.
And, personally, I have tried it and it helped me manage my pain drastically. You can find my personal journey, here.
Endo Research and Beyond
Your healing journey is not linear.
It’s not something you “push through.”
It’s something you soften into.
Supplements are not the answer —
but they are part of a holistic, grounded, powerful approach to supporting your body with endometriosis.
This post was all about the research-backed supplements that may support endometriosis healing, and how to integrate them with compassion and intention.
More About Endometriosis
- 7 Life-Changing Facts About Endometriosis
- Endometriosis Questions with Dr. Hawkins
- How to Help Endometriosis Pain
- 5 Best Products for Endometriosis
- Natural Endometriosis Pain Relief Manual
- Refreshing Beet Juice for Endometriosis Pain
HELLO
Meet Kyla
Hi Healthy Fam!
I am the creator of Pink Proverb — The Health and Wellness site for women focusing on being proactive about our healthy life and creating a self-care lifestyle that allows us to be our best selves.
I am a Stage IV Endometriosis mom, working hard to stay pain-free. This is my sacred place of inspiration, journaling the things that have helped me along the way.
For more, check out Healthy Kyla on Youtube!


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